Methods Development

While many clients come to Guild BioSciences to purify a single protein, others are interested in extracting groups of proteins with specific characteristics. For these clients, the challenge centers on the extraction process itself. Researchers unfamiliar with this process can spend considerable effort trying to achieve extractions that allow for specialized types of analysis. Achieving a high level of efficiency and enriching for specific protein subpopulations (e.g., those having specific solubility or insolubility characteristics, or specific biochemical attributes) can be frustrating due to a number of extraction parameters that can impact the specificity and absolute recovery of the extraction. Determining which aspects are key can be frustrating and time-consuming for even experienced scientists. Guild BioSciences has substantial experience in solubilizing and extracting protein from numerous types of starting materials, including highly targeted extractions. Guild BioSciences can leverage this expertise to develop optimized extraction methods and analyses for clients facing such challenges. Experts work closely with the client to build a method that fits the project’s specific needs, reducing development time and enhancing final performance. Partnering with Guild BioSciences for method development is much more efficient than developing the necessary expertise in-house and more cost-effective than adding temporary staff. Guild BioSciences staff members clearly explain the obstacles and solution options available to clients so that they are well-informed throughout the method development process, have genuine empowerment in overseeing the project, and can feel confident in reporting project progression.